Baclofen vs Flexeril: Uses, Precautions, Side Effects, Interactions

Muscle relaxants

Muscle relaxants are a group of drugs that cause numerous controversies as the abuse of these medicines is very common. In combination with specific substances like drugs and alcohol, it may even have a fatal outcome. That's why doctors are very cautious when prescribing therapy with some of these medicaments, although the conditions that they treat are not that serious.

Pain in muscles is something every one of us experiences almost every day, and most often it passes by itself with a lot of rest. However, in cases where rest is not sufficient, doctors prescribe therapy with muscle relaxants with mandatory consultation and checking the history of the disease.

The second name for this group of drugs is myorelaxants. Baclofen and Flexeril are typical representatives of this medication group, which affects the central nervous system. As with most drugs in this assortment, the exact mechanism of action of Baclofen has not been clarified, but it is assumed this gamma-aminobutyric acid derivative affects the pain receptors. It has the ability to block spinal cord reflexes by changing the polarity of nerve synapses in the reflex port. Baclofen represses the development of gamma-aminobutyric acid neurotransmitters, but there is still no key evidence about this process.

Flexeril vs Baclofen: Uses and Effects

Baclofen is used in the treatment of the first signs and symptoms of multiple sclerosis, while doctors mostly prescribe Flexeril for acute pain caused by injuries or damage to soft tissue. In the case of multiple sclerosis, patients feel cramps, and Baclofen can weaken this type of spasm. It alleviates both spasmodic pain and muscular stiffness. In patients suffering from this bone-muscular disorder, Baclofen helps to restore control over affected muscles. In addition to multiple sclerosis, Baclofen is also used to treat symptoms in spinal cord injury, but it is not used to treat muscle spasm due to rheumatic diseases. For such cases, doctors prefer to prescribe Flexeril.

Baclofen and Flexeril are two very effective representatives of the muscle relaxants group. When using any of them, it is important to have medical supervision. By no means, you shouldn't use these drugs without prior medical attention, even when it is only a common muscle cramp.

Currently, Baclofen is a drug preferred by physicians, given that its possibilities are still being tested. In recent experiments, scientists have tried to prove the effectiveness of this medication in treating alcoholism. Patients, who received Baclofen therapy, in almost half of the cases, were relieved of alcohol addiction or switched to "average" consumption. Even the absence of more severe side effects was noted, but volunteers reported mild symptoms such as drowsiness and increased fatigue.

On the other hand, the active ingredient of Flexeril is also an integral part of many generics that are often abused. In combination with alcohol, Flexeril exhibits several side effects, and in case of overdose, a fatal outcome can occur.

Flexeril vs Baclofen: Special Cautions and Side Effects

During the past trials, science proved that both Baclofen and Flexeril have analgesic effects on the brain, causing weakening of the reflex, drowsiness, as well as breathing and circulation issues. Also, a severe side effect of these medicines is the withdrawal syndrome, which can occur at the end of one's treatment. That's why the use of muscle relaxants demands enhanced monitoring.

Also, both drugs have a moderate sedative effect. At any moment, the muscle weakness may occur, and you can fall down. For this reason, the use of these medicines, especially Baclofen, is not recommended if a patient is planning any kind of physical activity that requires coordination and the full capacity of muscles.

The most common possible side effects in most muscle relaxants are drowsiness, nausea, and dizziness. Also, renal and cardiac patients should use this medicine with caution and regular control. When using Baclofen, there may be a blood pressure drop, and then fainting and migraine. Also, seizures and sleep disorders can occur, which is not registered in patients who are on Flexeril therapy.

It is noticeable that severe contraindications may occur in patients who are on the treatment with Baclofen, but that they are less frequent than in those who use Flexeril. Side effects that can cause this drug are milder but more common.

As for the effects of psycho-motor abilities, except for the possibilities already described for the occurrence of sudden muscle weakness in patients taking Baclofen, no consumption of any of the drugs mentioned is recommended if you plan to drive. Some doses can weaken your reflexes, and there is a chance that you bring yourself and others to danger.

Flexeril vs Baclofen: Drug Interactions

Medicines such as Baclofen and Flexeril are not prescribed to children, but there is a need for increased monitoring if used by older people, especially chronic patients. Be sure to tell your doctor about any additional treatment you take. Over 700 drugs have proven interactions with Baclofen and Flexeril, so do not risk your health. Doctors also avoid their simultaneous use as it may result in the intensification of negative symptoms, but also permanent damage to psychomotor functions.


Back pain is disturbing to both patients, as well as for doctors, even if it is acute. Many groups of medicines have not shown efficacy or have contributed very little to it, while severe side effects and Drug Interactions have been reported.

Newer generations of drugs such as Baclofen bring about significant improvements, but there remains fear that abuse can occur. Flexeril, which is longer in use than Baclofen, causes sedative side effects, and its inadequate use can lead to the addiction.

Except for its effectiveness, Baclofen is more competitive in terms of price and is more accessible to many patients. Considering the similar composition of Flexeril, the only disappointment is the side effects like insomnia, mood disturbance, breathing difficulties, etc.