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Antabuse Generic and Disulfiram drugs contain the same active substance
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In normal conditions, it is observed that during metabolism, alcohol is digested in the liver by the enzyme alcohol dehydrogenase to acetaldehyde. Further, it is transformed by the enzyme acetaldehyde dehydrogenase to the derivative of acetic acid. Antabuse Generic (Disulfiram) pill has tendency to avert this mechanism at the interim stage by stopping acetaldehyde dehydrogenase formation. When Disulfiram is combined with alcohol, it leads to raise the concentration of acetaldehyde in blood up to 5-10 times during metabolism. With the intake of alcohol along with Disulfiram causes hangover effects after 5-10 minutes. This hangover continues its dominating effects to the patients from 30 minutes to many hours depending upon body resistance. It possesses some symptoms to demonstrate the condition of patients. These include difficulty in breathing, nausea, postural syncope, mental confusion, throbbing headache, vomiting, flushing of the skin, increased heartbeat, circulatory collapse, and visual disturbance.
Antabuse Generic should be used under proper prescription of a physiotherapist. It should never be used after the consumption of alcohol as it has ability to make adverse effects. Disulfiram produces more damaging effects if more quantity is used. More quantity will cause more long effects of hangover. The effects of Disulfiram ingestion will remain up to 15 days as it is absorbed slowly from digestive tract of human body. It remains there for a long time as this drug escapes body in slow momentum. Therefore, it is imperative to mention its side effects to the patients.
In 2006, it was observed that controlled and recommended use of Disulfiram along with calcium carbimide during rehabilitation program for patients showed great results of success with abstinence rate of more than 50%.
Even controlled use of Disulfiram has no ability to minimize the patients' attraction towards the alcohol. This made Disulfiram a poor compliance drug for the treatment. In 1986, Fuller made a comprehensive study over extreme alcohol users. He concluded that those patients received counseling and the other group of patients who received Antabuse Generic for treatment showed no major difference in abstinence rates. It was considered that only 20% of the patients were in reasonable compliance with Disulfiram treatment. This compliance can be increased by using subdermal implant method. By this method a continuous release of drug is assured for almost 3 months' period along with the regular checkups of patients under custody.
Disulfiram has remained popular and recommended medication for the treatment of chronic alcoholics up to the 20th century. Presently, more medications have been introduced in the market with the claim of addressing physiological mechanism of patients directly. These medications include the amalgamation of naltrexone and acamprosate.
Antabuse Generic or Disulfiram is a medicine known by its tendency to create high sensitivity towards drinking of alcohol. Consequently, Antabuse tablet has its dominant effects in curing of chronic alcoholism. When mixed with alcohol, the drug produces enzyme called acetaldehyde dehydrogenase. This enzyme acts to inhibit the alcohol by creating "hangover" effect immediately to the alcohol consumer. Disulfiram mixed with alcohol creates devastating effects. Even small quantity of the drug can cause throbbing in head and neck, weakness, vertigo, blurred vision, thirst, chest pain, nausea, tachycardia, hypotension, palpitation, dyspnea, copious vomiting, sweating, hyperventilation, throbbing headache, respiratory difficulty, syncope, marked uneasiness, and confusion. Moreover, in some acute cases, Disulfiram can cause respiratory depression, myocardial infarction, convulsions, acute congestive heart failure, unconsciousness, cardiovascular collapse, arrhythmias and eventually death."
Antabuse Generic is a medicine that should only be used in different combination with some other medicines after the prescription of a physiotherapist. Because Disulfiram has great probability that it can convert alcohol to acetaldehyde in the body, which is then broken down by acetaldehyde dehydrogenase. This increased level of acetaldehyde in the body can cause damaging effects as dehydrogenase enzyme is inhibited.
Disulfiram has ability to avert the possible breakdown of dopamine. Dopamine is a neurotransmitter whose excess release can cause increased blood pressure, severe restlessness and anxiety. Excess release of dopamine is stimulated by consumption of cocaine. So, it is observed that Antabuse Generic can be used for the treatment of cocaine dependence, as it possesses antiprotozoal activity. Moreover, research for the treatment of HIV and cancer with Disulfiram is in progress.
When Disulfiram is mixed with the alcohol, it increases the level of concentration of acetaldehyde in blood up to 5 to 10 times during metabolism. Consequently, acetaldehyde produces damaging and devastating effects with alcohol. With the consumption of alcohol along with Disulfiram causes hangover effects after 5 to 10 minutes of alcohol ingestion. This hangover continues its dominating effects to the patients from 30 minutes to many hours depending upon body resistance.
In America, Occupational Safety and Health Administration (OSHA) has not provided any permissible exposure limit (PEL) for Disulfiram in the workplace. Consequently, the National Institute for Occupational Safety and Health has provided a recommended exposure limit (REL) of 2 mg/m3 and suggested that people should avoid concurrent exposure to ethylene dibromide.
Disulfiram has some side effects including garlic or metallic smell inside the mouth and headache. After the proper medication and treatment of Antabuse Generic tablets, a chemical compound called "Tryptophol" is produced in the liver which causes sleeping effect and dizziness to human body. There are some more side effects of this drug including nerve inflammation problem, skin redness, decrease in libido and liver issues to some extent.
It has also been observed that daily dose of prescribed amount of 500 mg Disulfiram is the reason to produce neuropathy. The need of the hour is to create awareness among masses about the criticality of the condition as the recent research work has pointed it out. Axonal degeneration has been observed during nerve biopsies. There has been a possibility that the neuropathy is hard to distinguish from associated effects towards chronic alcoholics. It has also observed that the Disulfiram neuropathy show its effects very slowly and consequently progresses steadily. Similarly, recovery from Antabuse Generic neuropathy is very slow and time taking.
Metabolism of paracetamol, caffeine and theophylline is disturbed by Antabuse Generic pills including many other compounds. This metabolism disturbance presents almost 20 to 40 percent enhancement is half-life of compounds at specific doses of Disulfiram packs.
Disulfiram is known by its medical property of creating unpleasant hypersensitivity towards alcohol. Similar effects are also caused by following medications.