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General Info: Uses and Effects
Clozaril Generic (active ingredient - Clozapine) is a leading antipsychotic medicine that is primarily used for the treatment of schizophrenia, especially in instances when patients develop resistance to other antipsychotic medication or treatment. It mainly works by altering the activities of the chemicals in the brain, which helps lower suicidal risks in people suffering from schizophrenia and related complications.
It was first manufactured way back in 1958 as the very first atypical antipsychotic and features on the World Health Organization's model list of essential medicines. The generic versions of Clozaril are available for sale in different parts of the world at cheaper prices but equally as effective, as the original. The tablet can however lead to low counts of white blood cells in the body which may even lead to death. To lower this risk, patients are advised to regularly monitor their blood.
Contraindication: Important to Know
Before taking Clozaril, it is important to consult your doctor and reveal your health and medical history. Note that this drug shouldn't be taken if you developed any form of severe allergic reactions or infections after taking it in the past. Also, don't use it to treat psychotic conditions linked to dementia, especially in older patients as it might increase risks of death.
It is important to inform your doctors if you have any of the following conditions:
- Heart-related complications, such as high blood pressure, heart diseases, history of stroke, or heart attacks;
- Kidney or liver diseases;
- Diabetes and associated risk factors like family history of diabetes or obesity/overweight;
- High levels of cholesterol in blood;
- Past or current cases of brain tumor, seizures, and head injury;
- Low potassium or magnesium levels in your blood, or similar electrolyte imbalance;
- Paralytic ileus (obstruction of the bowel).
Pregnant mothers are advised to consult their doctors because antipsychotic tablets can affect the newborn when taken during the last trimester of the pregnancy and can cause problems like tremor, breathing, feeding, fussiness, and stiffness of the muscles or limps. You also risk developing withdrawal symptoms or related complications if you stop taking the drugs during pregnancy. During this period, always consult your doctor.
Clozaril Generic can lead to seizures, slow heartbeats, dizziness, and fainting. To avoid injuries, you are urged to stay away from operating complex machinery, driving, or similar activities that requires high levels of concentration and alertness. If you are in a sitting or a lying position, get up slowly because you might feel dizziness and drowsiness that can make you fall which may cause body injuries. Stay away from alcohol and pills.
Instructions on Taking
Just like any other medicines, be cautious when taking Clozaril (Clozapine). Pay close attention to the doctor's instruction and the guidelines on the prescription label. Stick to the dosage, any change should be guided by the physician. You can take this drug with or without food.
Please bear in mind that this medication can lead to decreased volumes of blood cells, which may affect your body's ability to fight infections especially in the elderly, women, the malnourished or those suffering from serious medical conditions. These groups of people risk developing life-threatening infections when they take clozapine. Regular testing of the blood is therefore recommended.
In case you intend to undergo a surgical procedure, inform your surgeon in advance as you may be advised to suspend the treatment for some time. You are further urged not to stop taking this medication suddenly because your risk developing serious withdrawal symptoms; just talk to your doctor. In the event that you finally stop taking clozapine, you will have to undergo regular tests because the drug's effect on the body takes long to wither.
Any missed dosage should be taken as soon as you remember. However, you should skip it altogether if you remember it much later, especially almost the time for the next dose. Don't try to compensate the missed dosage by taking a double one. Contact your doctor if you miss 2 days consecutively. Immediately contact your physician or an emergency number if you accidentally over doses or come across someone who has.
Clozapine may have some serious but rare side effects, such as breathing difficulties, swelling of the tongue, throat, lips or face, skin pain, hives, fast spreading rash that cause peeling or blisters on the skin. It is also possible that you can develop serious infections, such as fevers, sore throat, breathing problems, cough, cold or flu, swollen gums, and painful sores in the mouth, among others. If you notice any of the above symptoms, don't hesitate to seek urgent medical attention.
Long-term use or high dosage of this pill can lead to irreversible but serious movement complications. You may experience unrestrained muscle movements of the face, legs, tongue, eyes, or lips. These symptoms are especially common in the elderly and women.
You are especially urged to contact your doctor if you experience the following conditions:
- Kidney-related problems, such as decreased, or no urination;
- Liver problems, such as jaundice, dark urine, lost appetite, exhaustion, unusual bleeding, among others;
- Headache, pain in the chest, and serious dizziness;
- Light-headedness that makes you feel like you are about to faint;
- Uncontrolled movement of muscles;
- Severe reactions of the nervous system, such as high fever, confusion, tremors, sweating, stiff muscles, pounding heartbeats;
- Symptoms of high blood sugar, such as dry mouth, increased thirst and urination, dry skin, weight loss, and drowsiness;
- Symptoms of inflammation like severe numbness, weakness of the muscles, or pain in upper stomach.
The following are some common side effects of Clozaril:
- Increased heart rate and sweating;
- Weight gain;
- Constipation and nausea;
- Blurred vision;
- Dizziness, tremor, sensation and head spinning;
- Drowsiness and headache;
- Feeling of dehydration such as increased salivation and dry mouth.
Interaction with Other Drugs
Clozaril can trigger serious heart complications, especially if used at the same time with other medicines. To avoid that, you should disclose all other drugs you are currently taking to your doctor before you commence treatment. Consult your physician before using anxiety, seizures, and depression medicines, sleeping pills, muscle relaxers, prescription drugs for coughs, and narcotic pain medicament. Disclose all antibiotics, anti-malarial drugs, anti-depressants, any medicine used for treatment of any psychiatric disorders, and heart rhythm medicines.