24 Jun 2017
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General Info: Uses and Effects
Depakote Generic (Divalproex) is an antiepileptic drug that has been approved for use in a psychiatric hospital in the treatment of bipolar disorder frenzied stage. Despite the fact that it is off-label and not yet officially approved by the FDA, the medicine is used in the longer term to stabilize the mood in bipolar disorder. Divalproex is also used to augment the effect of antidepressants during the treatment of serious anxiety and depression.
Currently, the treatment mechanism of Depakote is unknown, but is believed to be associated with an increase in the concentration of GABA (gamma-aminobutyric acid) found in the brain. Gamma-aminobutyric acid is recognized as a repressive neurotransmitter that slows the rate of firing in the brain and muscle cells.
Divalproex is not an addictive drug.
Contraindication: Important to Know
Depakote should not be recommended to patients suffering from hepatic disease or certain hepatic dysfunction, as well as from disorders of the urea cycle.
The Depakote Generic (Divalproex) medication is consulted in patients suffering from mitochondrial disorders that result from mutations in the mitochondrial DNA polymerase. It is also contraindicated for children under 2 years of age who are not trusted with disorders related to POLG.
Depakote is recommended for use in pregnant women suffering from migraine headaches.
Instructions on Taking
Divalproex can be used to treat mania, epilepsy, as well as to prevent migraine occurrence. Meanwhile, many people using this pill must be strictly monitored for possible severe side effects, such as pancreatitis and liver failure. Also, those women in the range of child-bearing should not use it unless there are advantages that supersede the risks and dependable contraception is applied.
The dosage is based on the doctor’s prescription and patient factors which include age, condition why the drug is prescribed, side effects sensitivity, nutritional position, and the dehydration presence.
When using the tablet, do not crush or chew it, but just swallow the whole. If you want to make swallowing much easier, most especially those that dislike swallowing tablets, open the capsule and sprinkle the content onto a pudding spoonful. Make sure you take this medicine with too much of water and maintain assert hydration all through the day. If you are having stomach disorder at the course of taking Depakote Generic, then eat some food or seek your doctor’s advice if you can quantify your doses very slowly.
Taking Divalproex can cause drowsiness thereby affect your driving or machinery operation, as well as abstain from taking alcohol.
Examine yourself if there are any changes, such as activities that are related to suicide mission, mood of depression, and agitation in your behavior. In case there is any, try and seek your doctor’s help in case the changes are ostensible. If you are experiencing stomach pain that extent to your back, vomiting and nausea, dark urination, appetite loss, swollen face or yellowish eyes or skin, then seek your doctor attention immediately.
Stay away from too much exposure to sunlight or tanning beds because Depakote Generic can allow you burn the more with ease. Put on sun-block and protective dresses anytime you are outdoors.
In order to monitor the effects of this medication, blood tests may be required.
The tablets are designed for oral use and are supplied in three dosage strengths in which each of the dose strength contains Divalproex Sodium that is almost the same as 125mg, 250mg or 500 mg of Valproic acid.
Seizures IQ: Depakote is administered at 10-15mg/kg every day. Then, it can be increased by 5mg-10mg/kg daily every week so as to attain the expected result. When the concentration of the blood is 50-100mcg per ml, then that is the expected result. It shows that it is responsive.
Acute Mania: If you are experience acute mania because of the bipolar disorder, the treatment begins with 750mg in a day of delayed-release tablets but the dose must be divided. Later, the dosage can be increased rapidly so as to attain the expected result. The highest dosage should be 60mg/kg in a day.
Migraines: The recommended dose of Divalproex is 250mg two times daily. The highest recommended dosage is 1000mg per day. If you are using extended release tablets, then the 500-1000 mg dosage once in a day is highly appreciated.
Due to the fact that one of the risks of Depakote Generic (Divalproex) is an increase in the chance of damaging the liver, it is necessary to monitor the following symptoms:
- Swollen face, arms, hands, legs, and feet;
- Dark urination;
- Stomach pain at the right side;
- Loss of appetite;
- Consistent vomiting;
Depakote has a high tendency to make a person suffering from suicidal thoughts. Immediately consult your doctor if you have any of the symptoms listed below:
- Panic attacks;
- Feeling restless or agitated;
- Anxiety and getting worse;
- Depression that later getting worse;
- Attempt to commit suicide;
- Thoughts of dying.
Common side effects are:
- Weight gain;
- Irregular menstrual periods;
- Hair loss;
- Ears ringing;
- Memory impairment;
- Seeing double;
Severe side effects include:
- Loss of consciousness;
- Feeling shivering;
- Swelling of hands or feet;
- Irregular heartbeat;
- Unexplained bleeding ;
- Chest pain.
Also, if you develop severe allergic reactions listed below at the course of Depakote Divalproex, seek your doctor’s advice immediately:
- Difficulty in breathing;
- Serious dizziness;
- Swelling tongue, face or throat;
Interaction with Other Drugs
The following pills listed interact moderately with Depakote Generic (Divalproex):
Additionally, there are certain anticonvulsants, hydantoins, and barbiturates that can interact with Divalproex.
Therefore, make sure you inform your doctor about all your medicaments you are taking so far and presently before commencing Depakote Generic (Divalproex).
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