5 Sept 2017
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General Info: Uses and Effects
Desyrel is a medicine used as an antidepressant. It comes in a tablet form for intake. Trazodone is used throughout the world for the treatment of many disorders including alcohol dependence, anxiety disorder, and depression. This drug is a phenylpiperazine compound of a serotonin antagonist and reuptake inhibitor (SARI) class.
Trazodone is available in the United States since 1981 as a generic medicine. Its cost in the USA for whole sale is $4.54 per month as of 2018.
Contraindication: Important to Know
Precautions must be taken for the patients having hypersensitivity to Trazodone. For the patients under the age of 18 years, Desyrel should be mixed with some other antidepressants to avoid any possible side effects of the medicine including feelings for a suicidal action. Those persons who take this drug for the treatment of depression are possible victims of suicide until remission of the dose occurs. Those patients who have higher intake of Trazodone are more prone to suicidal ideation.
Trazodone is not considered a member of the SSRI class of antidepressants. But it is researched that this drug contains certain properties of SSRIs. Moreover, it is believed that a discontinuation syndrome has greater possibilities if the medication is discontinued at early stage. It is practically recommended that the medication should be gradually tapered down the intake of Trazodone over a period of time.
The effects of the Desyrel intake during pregnancy or breastfeeding are not well researched. Moreover, it is believed that Trazodone has the ability to create impairment for tasks that include potential risk of driving an automobile or a machine. Thus, precautionary measures should be taken before using this drug.
Instructions on Taking
It is highly recommended that Desyrel should be used according to the prescription of a medical physician. No specific antidote is considered for this drug, as different quantities of Trazodone have different effects on different people. An overdose victim should be taken to hospital quickly. Gastric lavage is considered not useful if the drug intake has passed more than an hour. However, forced diuresis and activated charcoal are considered to minimize the effects of this medicine.
It has been observed that high intake of Trazodone causes serotonin syndrome. It has also been researched that taking Desyrel along with some other SSRIs also lead to serotonin syndrome.
In overdose conditions, the drug is considered to be the safe medicine as compared to the second generation antidepressants including MAOIs and TCAs. Even after the intake of high supplements of Trazodone up to 6-9.2 grams, very small uneventful recoveries have been observed. It was observed experimentally that 9 out of 294 patients were unrecoverable after intake of high dose of Desyrel. But it said that all nine cases of overdosed also intake depressants of central nervous systems along with this antidepressant. The most common and potential toxic effect of Trazodone overdose is hypertension. This serious and toxic effect should be carefully watched by physicians. With the 25.4mg/L dosage, there is a possibility of failure of multiple human organs. It was observed in a report that overdose of Desyrel causes atrioventricular block and torsades de pointes.
It has been reported that Trazodone is very helpful in conditions where antimuscarinic effects are created by other medications, for example patients with constipation, closed-angle glaucoma, and prostatic hyperplasia. The Desyrel ability to create sedation is another property of this medicine. Different quantities of this drug may offer different effects on patients. In some patients with anxiety and agitation, effects of the Trazodone dosage may be rapid. But in some patients with psychomotor retardation, the doses of the drug are tolerable.
Due to the alfa-1-adrenergic receptor blockade, Desyrel is observed to produce orthostatic hypotension in patients. People with the history of severe depression and bipolar disorder have greater chances to fall victims to those patients due to the Trazodone treatment.
Some common side effects of Desyrel include vomiting, drying of mouth, headache, priapism, heart beat irregularity, feeling for suicide, feeling faint, and unmasking bipolar. Trazodone has ability to create sedating effects.
In the patients with the personal and family histories of heart diseases and people with pre-existing mitral valve prolapse, the dosage of Trazodone can create cardiac arrhythmias. Symptoms of arrhythmia may include ventricular couplets, PVCs isolation, and 2-3 beats of ventricular tachycardia. Many reports are available in the market about the treatment of arrhythmia in context of the Desyrel medication. The effects of Trazodone were observed in both categories of patients including patients who had cardiac diseases and someone who had no cardiac disease. For cardiac arrhythmia, the patients of cardiac disease should be closely observed unless the detailed studies are not available. For the patients with initial recovery of myocardial, Trazodone is not recommended for use.
Due to antagonism at alpha-adrenergic receptor, priapism is a very rare side effect of Trazodone. For this side effect more than 200 cases have been observed. Moreover, abnormal erectile functions in men have been reported 1 in 6000 cases in which patients were treated with Desyrel. This side effect is more prominent during the treatment with this drug in initial stages. Even with the low dosage of 150mg/day, the abnormal effects in erectile function can be observed. The abnormality in erection should be reported in early stages, so that the medicine intake may be stopped immediately to minimize its side effects. Researchers also have analyzed the adverse reactions of Desyrel in women. As a result, it can increase libido, spontaneous orgasms. and priapism of the clitoris.
Interaction with Other Drugs
Trazodone is a well-absorbed medicine just after an oral ingestion in about 1 hour of intake. The absorption process is further increased by the food. Desyrel is immensely protein bound and easily metabolized with mCPP metabolites available in the human body. These metabolites have been reported to produce the serotonergic effects with the intake of Trazodone. These metabolites from human body have ability to increase the effects of the drug up to 10 times.
Consequently, patients who have intake of Desyrel come with a positive test on EMIT-II urine test for the confirmation of MDMA, it is due to the production of mCPP as a metabolite.
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