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Diflucan Generic (Fluconazole) is an antifungal drug that is used to treat various infections that are caused by fungi, such as candidiasis, pityriasis versicolor, histoplasmosis, coccidiodomycosis, blastomycosis, and dermatophytosis. The medicine is also used as a prevention drug against candidiasis, especially those at high risk of the disease such as underweight babies, those recovering from an organ transplant, and those with low counts of blood neutrophil. The drug comes in two forms: tablets and liquid form, taken orally or intravenously, respectively. Fluconazole is one of the World Health Organization's essential drugs that is FDA-approved in the United States and available worldwide under different brand names.
Compared to other antifungals, Diflucan Fluconazole is normally prescribed for the systematic treatment of fungal infections, especially because it is considered safer than other alternatives and has high absorption rates, especially when consumed orally. Some of the fungi are effective in killing candida, dermatophytes, Cryptococcus neoformans, and some dimorphic fungi.
What are the main medical uses
Doctors prescribe Diflucan Fluconazole for the treatment of the following conditions:
- Yeast infections that are mostly caused by candida, such as vaginal yeast, mouth, and throat;
- Some systematic candida infections on joints, kidney and blood. Doctors normally prescribe other antifungals if the infections are in the nervous system or the heart. It is also recommended for those whose immune system is considered weak;
- Candida infections in people whose immunity has been weakened because of other conditions, such as chemotherapy, organ transplant, HIV, and underweight infants;
- The treatment of central nervous system's fungal infection, also known as cryptococcal meningoencephalitis.
There are other conditions that the medicine can be prescribed, but that is at the discretion of the doctor after conducting requisite diagnosis on the patient. A series of tests may have to be conducted depending on the symptoms.
Absorption of Fluconazole takes approximately 2 hours. This however will depend on a number of factors, such as age, the overall health of the patient, and weight.
Is there any possibility of fungal resistance
Yes. Fungal resistance is common, especially when using antifungals as a long-term therapy. This is especially common in patients whose immunity has been compromised by other conditions such as advanced stages of HIV. It is especially common when treating candida infection on the esophagus and thrush. The resistance occurs through mutation which inhibits the binding of the drugs. When a patient develops resistance against some drugs, it applies across the whole class, in this case azole drugs. According to the Center for Disease Control and Prevention, there is an estimated 7% Diflucan Generic (Fluconazole) resistance amongst different types of candida in the United States.
Contraindication: Important to Know
Diflucan Fluconazole should not be taken by the following patients due to possible contraindication:
- Those taking SSRIs;
- Patients who are sensitive to other types of azole drugs;
- Taking quinine;
- Pregnant and breastfeeding mothers shouldn't use this drug as it can harm the fetus.
To avoid adverse side effects, it is recommended that patients disclose to their doctors the list if all medications they are taking, any specific allergies and overall state of their health. An alternative course of the treatment can be recommended in such cases to protect patients from the risks of severe side effects.
In as much as the symptoms may improve, that doesn't mean that all fungi have been eliminated by medicine. It is therefore advisable that you continue using Diflucan until such a time that you complete the prescription to avoid reoccurrence of the infection. Inform your doctor if the symptoms don't improve after using medication. Alternative treatment may be prescribed. It is however important to be patient when undergoing treatment, it might take some time.
The drug should be taken with strict adherence to the doctor's prescription. You should also read the leaflet on how best to take the medication. In case you miss a dose, you can either take it, if you remember it early, or skip it and resumed normal dosage. You should never be tempted to take more medicine with the hope of compensating for the missed dose or to expedite healing. This will only result in an overdose, which may have devastating effects. Common symptoms of overdose include fainting or difficulties breathing. You should seek urgent medical attention in such cases.
The medicine can be taken with or without food, in most cases once per day. For liquid suspensions, use a special measurement device provided with the medicine or a spoon. To boost efficiency, you are advised to take the drug at the same time daily because it works best when its level in the body is constant.
Similar to other drugs, using Diflucan Fluconazole can cause a number of side effects, such as vomiting, diarrhea, increase in liver enzymes, and skin rashes. Others include abdominal pain, nausea, fatigue, constipation, and anorexia. These are mild rashes that may disappear with time. However, there are some severe adverse reactions, such as seizures and liver problems. Don't hesitate to contact a doctor in case side effects persist or worsen.
Interaction with Other Drugs
Diflucan Fluconazole should be used with caution. It shouldn't be used with drugs such as Propulsid as it can cause severe and even fatal heart complications. It can also lower benzodiazepines metabolism and lead to an increase in the concentration of serum in citalopram and erythromycin. Consult your doctor for more information on common drug interactions. Disclosure of all medicines you are taking is also recommended for your own safety.
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