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General Info: Uses and Effects
Piracetam is the compound which is one of the leading Racetam's and is distributed under the brand name Nootropil. The name Nootropics comes from the Greek language and translates to "bending the mind". Chemically it is a cyclic derivative of gamma - Aminobutyric acid (GABA). Which is surprising because this medicine doesn't affect the GABA receptors in the brain.
It is a 'nootrope' which is basically a psychotropic agent. This acts on the telencephalon in both normal people and those suffering from some functional deficits. Telencephalon is grossly related to cognition, memory, alertness and consciousness. Nootropil drug will help with the severity of vestibular nystagmus. Nootropil also has a positive effect on aggregated platelets thus making it easier for them to pass through micro vessels.
Nootropil can act on the central Nervous system in a variety of ways. It will transform neurotransmission within the brain, and can help to improve the metabolic environment which is necessary for better functioning of neurons. Nootropil does not produce either sedation or stimulation. Nootropil can act on the central nervous system in a variety of ways.
This medicine is used in combination with other treatment for uncontainable jerking of the muscles, mostly in the arms and legs caused by a problem in the brain or nervous system. Severe mental cloudiness and vascular coma of a traumatic or toxic origin, chronic alcoholism and addiction. Piracetam is also useful to treat cortical myoclonus which is a movement disorder that causes jerky movements. It has been used to improve the neurological conditions of Alzheimer's disease, Dementia, Down's syndrome, and Dyslexia.
Before Starting Piracetam
Like most medicines Piracetam drugs also requires some caution whilst using it with certain conditions and diseases. It is essential that your doctor knows if you have any of the following before staring treatment:
- If you are pregnant, or trying for baby;
- Have any problem in blood clotting or undergoing warfarin/heparin therapy;
- If there is any type of bleeding;
- If you have problems with your kidney or liver;
- If you are taking thyroid hormones;
- If you are on controlled diet.
Piracetam pill may cause drowsiness and the user should not carry out skilled tasks such as driving or operating heavy machinery. Caution is required in treating patients with severe heart disease, the elderly or people with bleeding problems or who have recently undergone surgery. As Nootropil has an effect on platelet aggregation, one should take care if undergoing major surgery or suffering from any bleeding disorder. Also use it with care in patients suffering from renal insufficiency as it is almost exclusively eliminated by the kidney. Blood urea nitrogen and creatinine levels should be monitored regularly in patients with kidney impairment. Abrupt withdrawal of the medications should be avoided. Overdose is also avoided, in this case the nearest emergency medical unit should be visited. Also do not stop taking this medicine unless your doctor tells you otherwise.
This product is available in several forms, including injections, infusions, capsules, oral solutions, tablets, as well as bulk generic powder packs. It has a bitter taste so it is recommended to take with juice. Usually low doses therapy is started and then increased till the desired therapeutic benefits are achieved. It is advised to take this medicine several times daily due to short half life of this drug.
The standard Piracetam dose for children is between 40-100 mg per kilogram. This dose is used for the treatment of breath holding spells and child with dyslexia. The standard dose for adults is between 1,200-4,800 mg a day.
Myoclonus of cortical origin is usually treated with Nootropil 800 mg tablets.
Patients with a renal insufficiency with effects on gfr and creatinine clearance are usually advised to take a reduced dosage by their doctor, it may even be halved to salvage kidney function. Treat the patients with sickle cell anaemia by infusion of 80mg/kg in 300 ml of glucose solution every 8 hours for 3 days. After improvement of symptoms, followed by dosage of 1.2g orally 3 times daily. In case of chronic vertigo 1.2-2.4g in 2-3 divided doses is suggested.
Alongwith their useful effects, most medicines can cause unwanted effects although not experience by everyone. Symptoms of general excitability including anxiety, irritability, agitation and tremors are occasionally reported. Some patients may complain of fatigue or drowsiness. Nausea, vomiting, diarrhea, upset stomach gas and bloating have also been reported. Following is a list of the commonly reported side effects:
- Weight gain;
- Feeling weakness;
- Allergic skin reaction such as rashes;
- Headaches (in some cases these headaches can be reduced or even cured if a choline supplement is used along with Piracetam pills therapy).
Drug Interactions of Piracetam
Always consult a pharmacist or a doctor to determine whether nootropil tablets are appropriate for you to use. Some interactional have been reported with warfarin, acenocoumarol, lepirudin, heparins, glycoprotein IIb/IIIa receptors antagonists, phenindione, clopidogril, and Alteplase and streptokinase which are thrombolytic agents.
Piracetam tablets may increase the prothrombin time in patients who are taking anticoagulants such as warfarin. It may increase the risk of bleeding with other drugs with a similar effect on the blood. Piracetam may reduced the effect of anti convulsants if it is taken with anti epileptics.
Piracetam and alcohol combination has positive and negative effects. Alcohol reduces the brain efficacy while piracetam enhances it. Consumption of alcohol leads to cognitive impairment. It can help to settle some of the neurotransmitter receptors in the brain and make it easier to prevent memory loss that are related to alcoholic beverages. Combination of both will nullify the effect. Remember that piracetam intensifies the effect of alchohol which means you will need to drink much less to achieve the same state of intoxication. Various reviews claim that choline ( which increases piracetam efficacy and reduces some harmful effects) should be coupled with piracetam for superior effects.