1 Aug 2017
Very Good based on 12 reviews
1 inh @ $67.75 per inh
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General Info: Uses and Effects
Pulmicort contains an active ingredient called Budesonide. Pulmicort is a glucocorticosteroid with a high local anti-inflammatory effect, with a lower incidence and severity of adverse effects than those seen with oral corticosteroids.
The precise mechanism of action of glucocorticosteroids in the treatment of asthma is not fully understood. The anti-inflammatory action of Pulmicort due to the inhibition of the release of inflammatory mediators, as well as inhibition of cytokine-mediated immunological reactions is likely to be significant.
In a clinical study where asthmatics have used oral and inhaled Budesonide, a statistically significant efficacy of the inhaled but not oral Pulmicort has been shown compared to placebo. The therapeutic efficacy of inhaled Budesonide can be explained by a direct effect on the respiratory tract.
In one study, after a single dose of inhaled Pulmicort (inhalation powder), improvement in pulmonary function was achieved after only a few hours. The improvement in pulmonary function is expected 2 days after starting the drug, although the maximum effect is achieved after 4 weeks.
It has been shown that Pulmicort Budesonide reduces the airway reaction to histamine in hypersensitive patients. Use of this drug is also effective in preventing asthma caused by effort.
Pulmicort contains potent, non-halogenated corticosteroid Budesonide, which is used in the treatment of bronchial asthma.
This drug is also used in infants and children suffering from a viral infection of the upper respiratory tract known as viral laryngitis which usually requires hospitalization.
Contraindications: Important to Know
Pulmicort should not be used in patients who are allergic to its active substance Budesonide or other corticosteroids that have a similar chemical structure such as Fluticasone and Prednisolone.
Since corticosteroids can slow down the growth and development of children and adolescents, regular monitoring of the growth and psycho-physical development of the children is recommended. If growth is slowed down, the doctor must evaluate whether there is a benefit of a continuing therapy with this medicine or maybe he/she will decide to introduce a new drug.
Keep in mind that Pulmicort will not help you if you have an acute asthma attack. This medicine only prevents or reduces the frequency of asthma attacks.
Since most of this drug is excreted othroughver the liver, patients with hepatic impairment may have increased levels of Budesonide in the blood which leads to the appearance of adverse effects.
Pulmicort Budesonide is inhaled using appropriate device called nebulizer. The dose received by the patient varies depending on the equipment used for nebulization. The nebulization time and the delivered dosage depend on the flow rate and the volume of the nebulizer chamber.
The appropriate charging volume for most nebulizers is 2-4ml. The dosage of Pulmicort should be adjusted to individual needs of the each patient. In order to maintain good control of asthma symptoms, the dose should be adjusted to the lowest effective dosage. The maximum dose (2mg daily) for children under 12 years of age should only be considered in children with severe asthma during a limited period of time.
The recommended initial dosage of Pulmicort is as follows:
- Adults (including elderly) and children aged 12 years and older: 1-2mg twice daily. In severe cases, this dosage may be increased.
- Children aged 3 months to 12 years: 0.5-1mg twice a day.
The maintenance dose should be individually adjusted and reduced to the lowest effective one that maintains good control of asthma symptoms.
- Adults (including the elderly, as well as children aged 12 years and older): 0.5-1mg twice a day.
- Children aged 3 months to 12 years: 0.25-0.5mg twice a day.
Taking Pulmicort can significantly reduce the dose of oral corticosteroids in the treatment of asthma. Patient should not be switched from oral corticosteroid to Budesonide if he/she is not in stable condition.
After initiating Pulmicort in the therapy, the dose of oral corticosteroids should be gradually reduced to the lowest possible dosage. In many cases it is possible to completely replace the oral corticosteroid with Budesonide.
Pulmicort Budesonide can be mixed with saline solution and nebulization solutions of Terbutaline, Salbutamol, Phenoterol, Acetylcysteine, Chromoglyclic acid, and Ipratropium bromide. The prepared mixture should be used within 30 minutes.
Pulmicort Budesonide may cause the following side effects:
- Delayed hypersensitivity reactions;
- Oropharyngeal candidiasis;
- Immunological disorders;
- Skin rash;
- Contact dermatitis;
- Anaphylactic reaction;
- Endocrine disorders;
- Adrenal gland suppression;
- Vision disturbances;
- Psychiatric disorders;
- Psychomotor hyperactivity;
- Sleep disorders;
- Behavioral changes (predominantly in children);
- Respiratory problems;
- Throat irritation;
- Skin and subcutaneous tissue disorders;
Inform your doctor if you notice any side effects.
Interactions with Other Drugs
Pulmicort may enter into major interactions with more than 45 drugs, and in moderate interactions with more than 430 medicines.
Some of the most important interactions include:
- Amprenavir - a drug used to treat HIV infection. It increases absorption of Pulmicort in the body, which increases risk of side effects, such as cataracts, bruising, fat accumulation in the neck, and waist and hyperglycemia.
- Clarithromycin - a macrolide antibiotic used to treat bacterial infections. The concomitant use increases blood levels of Pulmicort, thus increasing the risk of side effects.
- Leflunomide - an immunosuppressant medicine used to treat various autoimmune disorders. The concomitant use increases risk of serious (possibly fatal) infections.
- Certolizumab - a drug used to treat Crohn's disease. The concomitant use increases risk of life-threatening infections.
- Boceprevir - a drug used to treat hepatitis C infections. It significantly increases blood levels of Pulmicort, thus increasing the risk of side effects.
- Fingolimid - a drug used to treat multiple sclerosis. The concomitant use increases risk of side effects, such as body sores, weight loss, diarrhea, fever, blood in phlegm, shortness of breath, etc.
- Golimumab - a drug that is used to treat rheumatoid arthritis. The concomitant use may severely impair your immune system, thus leading to severe infections.
- Ketoconazole, Itraconazole, Posaconazole, and other antifungal medicines - these drugs slow down the metabolism of Budesonide, thus increasing its levels in the blood.
- Smallpox vaccine.
Pulmicort Budesonide should not be used concomitantly with alcoholic beverages, because alcohol may increase the risk of side effects.
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